Sarcoma and other solid tumors

Protocol No. ClinicalTrials.gov Protocol No. PI Name Title
Pediatric Cancers > Solid Tumors > Liver Tumors
DFCI 19-338 NCT04134559 Rangaswami, Arun Checkpoint Inhibition In Pediatric Hepatocellular Carcinoma
Protocol No. ClinicalTrials.gov Protocol No. PI Name Title
Pediatric Cancers > Solid Tumors > Kidney Tumors
AREN1921 NCT04322318 Rangaswami, Arun A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT
Protocol No. ClinicalTrials.gov Protocol No. PI Name Title
Pediatric Cancers > Solid Tumors > Osteosarcoma
DFCI 20-086 NCT04417062 Vo, Kieuhoa Olaparib With Ceralasertib in Recurrent Osteosarcoma
PED-CITN-03 NCT04751383 Vo, Kieuhoa Testing the Combination of Two Immunotherapy Drugs (Magrolimab and Dinutuximab) in Patients With Relapsed or Refractory Neuroblastoma or Relapsed Osteosarcoma
PEPN1924 NCT04616560 Vo, Kieuhoa Trastuzumab Deruxtecan for the Treatment of HER2+ Newly Diagnosed or Recurrent Osteosarcoma
Protocol No. ClinicalTrials.gov Protocol No. PI Name Title
Pediatric Cancers > Solid Tumors
ADVL1921 NCT03709680 Vo, Kieuhoa Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors
APEC1621A NCT03213704 Rangaswami, Arun Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial)
APEC1621B NCT03210714 Rangaswami, Arun Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial)
APEC1621D NCT03213678 Rangaswami, Arun Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial)
APEC1621F NCT03213652 Rangaswami, Arun Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial)
APEC1621K NCT04195555 Rangaswami, Arun Ivosidenib in Treating Patients With Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With IDH1 Mutations (A Pediatric MATCH Treatment Trial)
APEC1621N NCT04320888 Rangaswami, Arun Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment Trial
APEC1621SC NCT03155620 Rangaswami, Arun Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)
DFCI 15-169 NCT02520713 Sabnis, Amit The iCat2, GAIN (Genomic Assessment Informs Novel Therapy) Consortium Study
PEPN2011 NCT04851119 Vo, Kieuhoa Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
PEPN2112 NCT05071209 Vo, Kieuhoa Elimusertib for the Treatment of Relapsed or Refractory Solid Tumors
ARST1921 NCT04195399 Rangaswami, Arun A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery